3-Hy­droxy-N′-[(E)-3-pyridyl­methyl­idene]-2-naphtho­hydrazide

The title compound, C17H13N3O2, displays an E configuration about the C=N bond. The mean planes of the pyridine and benzene rings make a dihedral angle of 31.2 (2)°. An intra­molecular O—H⋯O hydrogen bond is observed. In the crystal, inter­molecular N—H⋯N hydrogen bonding links the mol­ecules into a chain along [101]

An energy-efficient hardware system for robust and reliable heart rate monitoring

Cardiac arrhythmia, one of the most common causes of death in the world today, is not always effectively detected by regular examinations, as it usually occurs infrequently and suddenly. Therefore, real-time, continuous monitoring of the heart rate is needed to detect arrhythmia problems sooner and prevent their severe consequences. To make continuous monitoring possible and give it widespread acceptance, a portable heart rate monitoring system must have three key characteristics: (1) accuracy, (2) portability, and (3) long battery life. Previous studies have focused on addressing these problems separately, either improving the accuracy of the monitoring algorithm or the efficiency of the underlying hardware. This thesis proposes a robust and reliable heart rate monitoring system (RRHMS), in which both algorithm accuracy and hardware efficiency are considered. As a result, algorithmic optimizations are exploited to enable further hardware efficiency. In the RRHMS, robust heart rate monitoring is achieved by extracting heart rates from both electrocardiogram (ECG) and arterial blood pressure (ABP) signals and fusing them based on the signal qualities. Therefore, accurate heart rate data can be provided continuously, even when one signal is severely corrupted. Algorithmic optimizations are applied to merge the separate ECG and ABP processing steps into shared ones, which allows shared hardware modules and hence low-area (portable) hardware design. Also, an embedded hardware architecture framework is proposed for the design of the RRHMS hardware system. Coarse-grained functional units (FUs) can be easily added or removed in this framework, allowing for application-specific hardware optimization. Further, the application invariant properties are used to achieve low-overhead fault tolerance in the FUs to enhance reliability. Both ASIC and FPGA implementations of the RRHMS are able to accurately detect heart rates in real time while consuming only 1/2870 and 1/923 of the energy required by the Android implementation

Basic aluminum sulfate@graphene hydrogel composites: preparation and application for removal of fluoride

National Natural Science Foundation of China [21104041]Porous composites based on basic aluminum sulfate and graphene hydrogel (BAS@GHG) were prepared via homogeneous precipitation of BAS in GHG, and used as adsorbents for fluoride removal from water. The BAS@GHG composites have a porous structure with a chemically converted graphene three dimensional network coated by a thin layer of amorphous BAS. These composites showed high adsorption capacities of up to 33.4 mg g(-1) at equilibrium fluoride concentrations of 10.7 mg L-1 and temperatures of 298 K, higher than those of previously reported graphene and aluminum-based adsorbents. The adsorption kinetics and isotherm were analyzed by fitting experimental data with pseudo-first-order kinetics, the Weber-Morris model and Langmuir equations. The effects of temperature, pH value, and co-existing anions on the adsorption of fluoride were also investigated

Effects of electronic structure and interfacial interaction between metal-quinoline complexes and TiO 2 on visible light photocatalytic activity of TiO 2

Two metal-quinoline complexes, Fe(III)-8-hydroxyquinoline-5-sulfonic acid (Fe-HQS) and Er(III)-8-hydroxyquinoline-5-sulfonic acid (Er-HQS), were used as sensitizers of TiO 2 for improving visible light photocatalytic activity of TiO 2 . UV-vis spectra, X-ray Diffraction, X-ray Photoelectron Spectroscopy, Scanning Electron Microscope and Transmission Electron Microscope were put to use to characterize the structure and morphology of Fe-HQS-TiO 2 and Er-HQS-TiO 2 . The effects of interfacial electron transfer and energy level matching between each complex and TiO 2 were researched intensively. Er-HQS-TiO 2 and Fe-HQS-TiO 2 exhibited enhanced photocatalytic activity on photodecomposition of phenol in aqueous solution under visible light irradiation comparing to that of pure TiO 2 . According to photoelectrochemical response property and theoretical calculation of energy levels, two possible energy matching modes and photoelectron transmission pathways were proposed to explain the effects of Fe-HQS and Er-HQS on the interfacial interaction between metal-HQS complex and TiO 2 , and their different photocatalytic activities under visible light irradiation. The work in this paper indicated that metal-HQS complex with appropriate electronic structure and HOMO-LUMO energy levels relative to the band gap of TiO 2 played a major role in improving TiO 2 photocatalytic activity

An Analysis of the English Translation of The Class Struggles in France Based on AntConc

Studying Marx’s analysis of class struggles in France provides insight into historical socio-economic dynamics, revealing patterns of oppression, resistance, and revolution. It elucidates the role of the bourgeoisie and proletariat in shaping societal structures, informing contemporary understanding of power dynamics, inequality, and potential pathways for social change. Based on the English version of the Class Struggles in France, the language use and organization of it are analysed by using the retrieval and analysis functions of AntConc. Through the analysis, its language features are concise, clear structure, strong logicality, key terms centred around the main theme, and a coherent logical relationship. The vocabulary used exhibits emotional tendencies, particularly concerning communism and capitalism, highlighting the author’s emotional attitude

Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis

BackgroundMedulloblastoma (MB) is the most common malignant brain tumour in children but also rarely occur in adults. Sonic Hedgehog (SHH) driven MB is associated with aberrant activation of the SHH signalling pathway. SMO inhibitors, sonidegib and vismodegib, have been used as selective antagonist of the hedgehog pathway that acts by binding to SMO, and inhibits activation of the downstream hedgehog target genes. Several clinical trials investigating SMO inhibitors for the treatment of relapsed MB patients have been published.MethodsWe conducted a systemic review and meta-analysis among these Phase I and II clinical trials. The pooled effect of SMO inhibitors in relapsed MB were analysed using Reviewer Manager 5.3 software. The clinical efficacy of SMO inhibitors on SHH subtype of MB were measured by the objective response rate. The risk difference was obtained by comparing the ORR between SHH and non-SHH subtypes of MB.ResultsThe five studies all had clear criteria for patient recruitment, adequate follow-up time for endpoint assessment and clear definition of tumour responses. MB patients had good compliance in the trials. The pooled objective response rate (ORR) of SMO inhibitor was 37% and 0 against SHH-driven and other MBs. The pooled ORR of sonidegib was 55% among MBSHH and 0 among MBnon-SHH subgroup. Vismodegib also had no efficacy on non-SHH subtype of MB. The sonidegib against SHH-driven MB produced the ORR 1.87-fold higher than that of vismodegib (95%CI 1.23, 6.69). Among paediatric patients, the efficacy of sonidegib was 3.67-fold higher than vismodegib (